A- A+

Collagen safety study

In an eight week clinical study, involving 58 women, researchers found a significant improvement in skin quality among Toki users. Side effects were both limited and quickly resolved. The discussion of Toki safety from that published study is presented below:

A CLINICAL EVALUATION OF THE SAFETY AND EFFICACY OF DIETARY FORMULATION IN IMPROVEMENT OF AGE-RELATED SKIN CHANGES IN WOMEN WITH MODERATE TO SEVERE WRINKLING OF THE PERIORBITAL AREA
Irwin Kantor, MD, FAAD, Louise A. Donikyan, DO, Randi Simon, BS, Bernd Wollschlager, MD
RTL, Inc., Hackensack, New Jersey
Clinical Assistant Professor of Medicine and Family Medicine, University of Miami School of Medicine, Miami, Florida

The Journal of the American Nutraceutical Association (JANA) (2002) Vol 5,2 : 10-19

SAFETY
During the course of this study, a total of 13 subjects presented with 22 adverse reactions of all types (sever A treatment subjects with nine, six B treatment subjects with 13). All reactions were resolved.

Of the total number of adverse reactions, Group A treatment subjects Nos 2, 30 and 38 presented with three possibly product-related adverse reactions and Group B treatment subject No. 17 presented with three possible product related reactions. With the exception of a mild pruritus of the extremities over 3 days (No. 17) , all other possibly-related reactions were gastrointestinal nature (diarrhea and one case of nausea). Of the these reactions was moderate in severity (No. 38) , while all others were mild. Overall, under the conditions of this study, the dietary collagen treatments were apparently safe to use.