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Toki Studies

The Science of Toki
The skin is divided in 2 main portions; the upper layer is the Epidermis and the lower layer is the Dermis. The bottom layer of the Epidermis is where pigment-producing cells live (melanocytes), where our skin color is produced as well as less desirable skin tones and overall skin discolorations (freckles, dark spots). These can also be due to sun damage.

The Dermis goes through many changes in the aging process. The Dermis is where the capillaries that bring blood flow to the skin live. When Collagen and Elastin fibers begin to break down, it may lead to skin weakness, or sagging (fine wrinkles lines). The overuse of facial muscle will also cause deep wrinkles (squinting, frowning, smiling). Because TOKI is taken internally (in the form of a drink), it can help deliver nutrients to the dermis (lower layer). The result: A total body solution that supports a youthful appearance.*


Toki Clinical Studies

STUDY 1: A CLINICAL EVALUATION OF THE SAFETY AND EFFICACY OF DIETARY FORMULATION IN IMPROVEMENT OF AGE-RELATED SKIN CHANGES IN WOMEN WITH MODERATE TO SEVERE WRINKLING OF THE PERIORBITAL AREA
Irwin Kantor, MD, FAAD, Louise A.Donikyan, DO, Randi Simon, BS, Bernd Wollschlager, MD
RTL, Inc., Hackensack, New Jersey
Clinical Assistant Professor of Medicine and Family Medicine, University of Miami School of Medicine, Miami, Florida

The Journal of the American Nutraceutical Association (JANA) (2002) Vol 5,2 : 10-19

ABSTRACT

Context:
The relationship between dietary supplement and the repair of aging skin is unclear.

Objective: To assess the safety and efficacy of a dietary formulation for the improvement of age -related degenerative skin changes in women

Methods: Using a blinded, randomized, parallel design, a total of 40 women, age 35-65 years were enrolled and divided into approximately balanced groups with 38 women completing this eight-week, four-visit study. Recommended daily doses of the study product, a dietary collagen formulation (Toki), were 7.5g (given to Group A) and 8.5g (given to Group B). Both investigator and subjects assessed skin wrinkling and other skin characteristics in the periorbital ("eye") area as well as overall facing aging.

Main Outcome Measures: Safety and Efficacy of a dietary collagen formulation when used to improved periorbital wrinkling, aging, sagging, and puffiness and periorbital overall facial aging.

Results: The consumption of dietary collagen formulation resulted in highly statistically significant improvement in periorbital wrinkling, in periorbital aging and in periorbital overall facial aging. The investigator’s mean global improvement scores of overall facial appearance as compared to baseline photographs were highly significant. Significant improvement was noted as early as two weeks.

Conclusion: In women with age-related skin changes, a dietary collagen formulation (Toki) significantly improved periorbital wrinkling, periorbital aging, and periorbital overall facial aging with minimal adverse effects.

Case Study 1. Patchy Discolorations


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Case Study 2. Under Eye


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Case Study 3. Patchy Discolorations


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Case Study 4. Fine Lines "Crows Feet"


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Self Observations -Toki users reported firmer, more pliant skin, less noticeable the appearance of fine lines and wrinkles, and improvements in skin color.

Other Findings -The study also revealed that Toki was most effective for those who did not smoke or did not have extensive sun-damage.

Read Complete Published Study Here


STUDY 2: ABSORPTION OF TOKI MEASURED BY BLOOD COLLAGEN ASSAY

Absorption of collagen form Toki was assessed by measuring levels of serum collagen. Hydroxyproline (amino acid component of collagen) levels were measured and converted to equivalent levels of porcine collagen. Serum collagen levels were tested at baseline, study day 15 and study day 30. Clinical evaluations, performed by a board-certified dermatologist, and subjective evaluations were used to determine the effectiveness of Toki in improving skin appearance. Clinical assessments and subjective evaluations were performed at day 15, study day 30 and study day 60.

Absorption of collagen form Toki was assessed by measuring levels of serum collagen. Hydroxyproline (amino acid component of collagen) levels were measured and converted to equivalent levels of porcine collagen. Serum collagen levels were tested at baseline, study day 15 and study day 30. A statistically significant increase in hydroxyproline was observed at both day 15 and day 30 as compared to baseline, suggesting a high rate of absorption of Toki collagen.

Read Study Results Here


STUDY 3: SKIN IMPEDENCE AND JOINT HEALTH

Researchers at Katsuragi Hospital in Japan discovered skin improvements in people who ingested Toki (described as AAACa calcium with collagen and other matrix components). In this 80 person case controlled study, changes were measured between an individual taking Toki and a similar subject who took nothing. The researchers noted that “basal skin impedance, which increases with age, was significantly reduced in response to the Ca-collagen matrix [i.e. Toki] supplementation, suggesting a change in skin properties similar to rejuvenation, along with subjective smoothening and moistening of the skin.